Ministry of Hemp

Ministry of Hemp

America's leading advocate for hemp

Category: Hemp CBD Oil

RE Botanicals Hemp Tincture Offers Silky Smooth CBD With No Aftertaste

RE Botanicals Hemp Tincture tasted great and eased our chronic pain, with a mild, delicious hemp flavor. Even better, they support organic farming and regenerative agriculture.

We truly enjoyed trying RE Botanicals Hemp Tincture, a very high quality CBD oil.

The care that RE Botanicals puts into their products shines through from the start. Everything about their tincture exudes quality and elegance, from the twist off cap, the ease and responsiveness of the dropper to the clean looking package. We knew this hemp extract was going to be an experience!

Upon opening, we immediately noticed a fresh hemp scent that wasn’t overpowering, but strong enough that we just knew quality hemp was used. The extract itself was almost colorless with just an ever so slightly yellowish tint.

The taste didn’t disappoint either. The team ingested the CBD in three ways: sublingually, on the tongue, and in coffee. All three ways yielded the same results: a nice silky texture that didn’t leave an aftertaste like some extracts we’ve tried. Yet there was still a modest hemp taste that we all enjoyed. Even when we put RE Botanicals Hemp Tincture directly into coffee, the coffee taste wasn’t altered much, which can sometimes happen with CBD extracts. Our team also found this extract effective at reducing chronic pain and relaxing to consume, too.

RE Botanicals Hemp Tincture tastes great, and left our reviewers feeling relaxed. Photo: RE Botanicals Hemp Tincture bottles on top of a wooden surface decorated with flowers.

RE Botanicals Hemp Tincture tastes great, and left our reviewers feeling relaxed.

RE Botanicals paid us a fee and offered us free products in return for our honest opinion. If you purchase a product from one of these links, we’ll receive a percentage of sales. Read more about sponsored content on Ministry of Hemp.

Read on to learn more about RE Botanicals and see our complete product breakdown.


RE Botanicals is proud of their sustainable growing methods.

John Roulac founded RE Botanicals after 20 years in the hemp industry. In 1999, long before creating RE Botanicals, he founded the superfood brand Nutiva. Roulac and RE Botanicals focus on organic and regenerative agriculture. Regenerative agriculture is a holistic land management practice that closes the carbon cycle, builds soil health, crop resilience and nutrient density. One percent of all RE Botanicals sales are donated to support regenerative agriculture and help farmers create healthier soil.

According to RE Botanicals, the extract process starts with organically grown hemp. This helps maintain healthy soil biology. Hemp is climate-friendly because it sequesters carbon in the soil. They use a proprietary alcohol extraction method that employs a full spectrum extract, never an isolate. RE Botanicals then blends the full-spectrum organic hemp with organic MCT coconut oil from young coconuts.

At first, we were somewhat confused by the labeling, until we realized that RE Botanicals Hemp Extract is labeled by the dose, rather than per bottle. This contrasts with many other CBD brands on the market. At 25mg of CBD per dropper, that makes 750mg of CBD per bottle, a fairly standard amount.

Other than this, RE Botanicals tincture is clearly labeled with a bottle that’s easy to read and lists all the ingredients. We also appreciate that they make their lab tests easily available on their website.

RE Botanicals Hemp Tincture Classic 25MG (Ministry Of Hemp Official CBD Review)RE BOTANICALS HEMP TINCTURE OFFICIAL REVIEW

  • Highlights: RE Botanicals Hemp Tincture is an effective, high-quality CBD oil with a silky texture and a clean hemp taste.
  • Strength: 25mg per dropper, 750mg per 30ml bottle, also available in 15mg and 50mg strengths
  • Price: $49.99 – $139.99
  • Customer Service & Shipping: Fast, friendly customer service. Free shipping available on orders over $50.
  • Independent Test Results: Online.
  • Flavor & Texture: This unflavored tincture tastes mildly earthy, with notes of green tea, with a pleasantly silky texture and almost no aftertaste.
  • Ingredients: CBD oil / Full Spectrum Hemp extract in Organic MCT (Coconut-based) oil.
  • Other: RE Botanicals offers a generous 30-day, money back guarantee for unsatisfied customers.

RE Botanicals uses U.S. hemp, grown under organic methods, in all their products. In addition to tinctures, RE Botanicals offers CBD capsules and CBD for pets.

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Cannabis Testing Labs: The Problem With Hemp & Cannabis Lab Testing

Hemp and cannabis brands depend on cannabis testing labs to verify the purity and quality of their products. The inconsistency of cannabis testing labs is indicative of a much bigger problem, which is the lack of checks and balances in the cannabis industry.

The inconsistency of cannabis testing labs is indicative of a much bigger problem, which is the lack of checks and balances in the cannabis industry.

One of the largest problems in the cannabis industry is the inconsistency of quality control.

Buying a cannabis product, from CBD oil to psychoactive cannabis, can be quite scary for a consumer. Due to the lack of standardized product testing, you don’t fully know if the producer’s claims are truthful, if the correct dosage is listed, or exactly what’s is in the product.

The government maintains strict controls over the quality of our food, and supplements and medicines we buy over-the-counter and get from pharmacists. Right now, the cannabis industry doesn’t have that. Instead consumers are forced to trust the word of companies which can obviously leads to issues.

There's growing demand on cannabis & hemp product testing labs, but also renewed attention on their inconsistencies too. Photo: A gloved scientist with a vial of CBD and a hemp leaf.

There’s growing demand on cannabis & hemp product testing labs, but also renewed attention on their inconsistencies too.

This problem isn’t simply due to the companies that produce the products, but also to the cannabis testing labs themselves. There’s no doubt that testing is important, but without better standards can we rely on those test results?


As revealed by Forbes, not all cannabis testing labs are created equal.

There’s no minimum requirements for things such as equipment, certifications, and merit for lab testers. As a result, cannabis testing labs can vary dramatically from each other.

The biggest problem though, is the lack of a standardized method for testing the various cannabis products. This can mean that the testing procedures for quality and potency of a hemp plant varies dramatically from hemp oil, distillates, to edibles and beyond. The problems multiply since different labs all have different testing methods, claiming that their methods are more effective than others and can give superior results.

The problem is that this creates inconsistencies in the results, since not all labs are using the same method for testing. This obviously can’t continue to happen. Without standardized testing methods for each cannabis product, the results will continue to be inconsistent which defeats the purpose for testing the product in the first place.


When a company markets a certain product, they want certification for their product, so their consumers can trust the quality of their product. To get these certifications, the companies have to send a batch of product to a testing facility to test for things such as potency, effectiveness, etc.

Problem arise when those results vary from lab to lab, leading to confusion about the quality of the product. This may even be due to the “friendliness” of certain labs over others, freely manipulating the results to meet the expectations of the producers. Manufacturers aren’t the only ones who test their products. Growers test their cannabis for quality too. With their reputations on the line, they want the best test results possible, so it proves the quality of their cannabis or hemp and hopefully leads to more companies wanting them as a supplier.

But again, with the lack of oversight, growers can substitute the product sent to the labs with a more expensive and higher-quality product, thus producing false results for their crops. Of course, this imply doesn’t that all cannabis testing labs and growers do this, but with the lack of standardized guidelines and someone to enforce those guidelines, it’s something that can happen without any real repercussions.


On top of all of this, the business model for the labs themselves are flawed. The costs for lab equipment, buildings, electricity, accreditation, and salaries for lab testers are all very expensive. On the contrary, the going rate for a test on a single batch is typically under $200. Meaning in order for these testing facilities to make a profit and succeed as a business, they have to operate in a high-volume capacity.

While cannabis companies grow at a stunning pace, demand for the labs which test these products grows too. These cannabis testing labs are much different from their government-ran cousins, which have access to more capital, a better talent pool, more experience, and the power of the federal government behind them.

From the expensive startup costs, ferocious competition, increasing pressure from growers & manufacturers and no one to keep them in check, why wouldn’t a laboratory fix their reports for better results? Again, we’re not claiming any or even most labs do this, but there’s little oversight on their results.


This issue goes beyond the testing companies, as the lack of regulation affects the entire supply-chain of the cannabis and hemp industries.

In other words, if no one is keeping the cannabis testing labs in check, then there is certainly no one keeping the growers, transporters, dispensaries, or producers in check. All of this leads to a lower quality product, and one that consumers can’t trust. If this continues to be the case, a distrust can develop between company and consumer. The cannabis industry has grown both in popularity and revenue in the past decade, and a loose-knit system that depends on hand-shake deals and trust is quite simply just not enough for long-term growth.

Fortunately, industry leaders are trying to improve the cannabis supply-chain.


So how do we solve this problem and all the other problems present in the cannabis and industries? How do we make sure that the companies we purchase from are actually telling the truth, and that there aren’t any unwanted substances in the product?

Increased federal oversight could help improve the quality of cannabis testing labs, and cannabis and hemp products in general. Photo: A scientist in gloves and a white lab coat examines a test tube of green liquid, with a microscope nearby.

Increased federal oversight could help improve the quality of cannabis testing labs, and cannabis and hemp products in general.

We do this by getting support from the federal government. The federal government is the only entity that can effectively enforce regulations upon the cannabis industry that will keep the different sectors in check. Not only do they have the power of enforcement, but they are the only ones to have the resources capable of quality-checking every part of the cannabis supply-chain.

To add to that, the federal government also has the power to enhance other parts of the industry. In addition to quality control, they can regulate things such as financing, shipping, and further research into cannabis. In fact, federal regulatory support is the single greatest challenge to the entire industry. The support for cannabis is already here, with a large portion of congressman and senators publicly backing the plant. Now we need those people in power to start implementing systems that help build up the industry.

There are signs that this is happening, especially thanks to the recent legalization of industrial hemp in the 2018 Farm Bill. But there’s still a long way to go.

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The High Cost Of CBD: Why Is CBD Expensive?

Why is CBD so darn expensive? The reasons range from expensive equipment for CBD extraction, to the high price of banking and insurance.

Why is CBD so darn expensive? We wanted to take a closer look at the high cost of CBD.

CBD is expensive! There’s no getting around the fact that when you buy CBD your pocket book’s going to take a bit of a hit.

On average, we see the price of CBD per milligram around $.15. If a standard 30-milliliter tincture contains 500 milligrams of CBD, you can expect to pay around $75.00, not including tax and possibly shipping for online shoppers.

That might be acceptable for some, but cash-strapped consumers may not have the disposable income to keep up with a consistent dosing regimen needed to manage their ailments. When this happens, patients may end up looking to inferior CBD products that can be incorrectly labeled, impure, or even unsafe rather than lab tested, high-quality CBD.

CBD oil helps so many people, but why is CBD expensive? We took a closer look at some of the costs that go into making the supplement. Photo: A collection of CBD tinctures in assorted bottles, decorated with hemp buds.

CBD oil helps so many people, but why is CBD expensive? We took a closer look at some of the costs that go into making the supplement.

If you’re curious as to why CBD is so costly, read on because we’re going to breakdown the costs associated with CBD products, and provide tips on stretching your CBD dollar as far as possible.


As with any agricultural farming, the first set of costs are the land and farming and cultivation costs such as; seeds, labor, cultivation equipment, state, city, and county licenses, etc.

With regards to farming hemp (and marijuana) there are additional reporting and testing costs over other agriculture due to the nature of what’s being planted and each state has their own set of requirements and costs. These costs can be as low as $25 in Vermont and as high as $500-$1000 depending on whether the license is for a grower or hander, plus a $5.00 per acre fee. To get a better idea of costs, we recently published an article overviewing the hemp market for Nevada, Vermont, Oregon, and Wisconsin.

Some states also have specific licenses or certification programs for hemp seed distributors and producers. Click to read each state’s hemp statutes.


Once the hemp plants reach maturity it’s time to harvest them. According to, the cost to harvest an acre of hemp in Minnesota will run between $300 to $600 per acre. This is down substantially from 2017 when the cost averaged between $970 to $2,500 per acre.

Once the harvest is complete, the hemp plant stem needs to have the various components separated with a machine called a decorticator. This machine can run upwards of $2 million.

After decortication, the next step will be to extract the cannabinoids, terpenes, flavonoids, etc. from the plant. The two most popular methods of extractions are through a Supercritical CO2 extraction or an ethanol extraction with CO2 extraction becoming the standard.

According to Cannabis Business Executive, a CO2 extraction machine can cost around $135,000 to $150,000 plus $20,000 to $35,000 for a rotary evaporator and centrifuge.

Of course these machine costs are in addition to the buildings, infrastructure, labor, and the raw materials for those not growing their own.


Once the cannabinoids, terpenes, and other plant materials are extracted from the cannabis or hemp plant, there are still a number of steps needed before the CBD reaches store shelves.

What is initially extracted is a cannabis concentrate that has contains acids that need to be decarboxylated. The cost for a decarboxylation oven cost around $5,000 to $7,000 for ovens that have a capacity of 10 cubic feet and can go up to 38 cubic feet.

After the concentrate is decarboxylated, what’s left is full spectrum cannabinoid oil. Full of all the cannabis plants cannabinoids, including CBD, terpenes, and the plants chlorophyll, lipids and waxes. When it comes to the “entourage effect,” this is the best option.

However, not everyone wants the plant materials and/or the THC. Many patients prefer oil with higher concentrations of cannabidiol (CBD) and not concerned with plant properties or THC. To remove the plant properties, the CBD concentrate will first be winterized to isolate and remove the unwanted compounds, followed by distillation to further ‘clean’ the oil. If THC is being removed, the distilled concentrate will then go through a chromatography machine. Cost for the equipment to perform these functions can grow to the hundreds of thousands plus the labor to run them.


Once complete, the finished product now needs to be tested to prove product purity and concentration. There are a variety of tests available. Following are a list of services by a well known testing facility in Arizona.

Testing Services:

  • 10 cannabinoids ($50/bottle)
  • Mold and fungus screening ($25/bottle)
  • 19 Residual Solvents ($35/bottle)
  • 41 Terpenes ($40/bottle)
  • Moisture Content ($15/bottle)
  • 4 Microbial Analyses ($40/each count)
  • Custom Services

After testing, the CBD concentrates are bottled, packaged and prepared for delivery to their distributors to sell.


Obviously the largest costs come from the manufacturing side, but we can’t forget about the product distributors who have their own set of operating costs. Operating costs themselves are just a part of doing business. But operating costs for cannabis companies can be twice, even three times as much. In addition, due to the ‘gray’ area of cannabis and hemp laws, CBD companies must take extra precautions to insure they are protected. This, of course, adds to the cost of CBD.

Other factors that increase the cost of CBD include retaining a lawyer, hiring an in-house compliance officer, and the complicated nature of banking and insurance in the hemp and cannabis industries. Photo: A lawyer in a suit and tie writes on a notepad while talking on a smartphone in an office.

Other factors that increase the cost of CBD include retaining a lawyer, hiring an in-house compliance officer, and the complicated nature of banking and insurance in the hemp and cannabis industries.

Let’s take a look at the bare minimum of operating costs a CBD company is going to incur.


A general liability business insurance policy for cannabis companies can easily amount to $500 to $700 per month! This same insurance policy for a non-cannabis company would only be about $700 for a year!

Credit Card Processing

Credit card and banking options are very limited for cannabis companies. In order to accept credit cards for hemp purchases distributors need to sign up with merchants specializing in ‘high risk’ processing. Costs with these processors can be exorbitant. In some cases they can run hundreds of dollars per month.

If a high-risk domestic merchant cannot help, distributors are then forced to look off shore for credit card processing. These don’t come cheap. Off shore processors will normally require a business to incorporate in the country that processes the cards. Incorporating in the UK costs roughly $500 plus monthly fees that can also run in the hundreds per month. These are in addition to the higher-than-normal monthly processing fees for the service.


Bank accounts and business loans are not available to cannabis companies, which means they need to find unique, and sometimes costly, places to store their cash and have access to it for payroll and other business related expenses. Again, this often results in the opening of costly offshore accounts.

In-House Compliance Officers

Since the state level requirements for CBD derived from hemp and marijuana differ, CBD companies usually have someone in-house make sure the company is adhering to each state’s regulations. They also make sure all the products meet the specific states allowed THC percentage. In most cases, this is 0.3 percent THC or less. They also monitor the percentage of CBD contained in the products are inline with the product labels.

An article from states that according to the FDA, 69 percent of CBD products are mislabeled. In-house compliance officers work to insure this doesn’t happen.


A company selling CBD better have an attorney. If not, they’re taking big risks. Attorneys will help insure companies are acting in compliance and keeping up with the ever-changing state laws on cannabis.

Countless stories have come to surface about CBD companies getting hassled by police, and in come cases even getting arrested! A good attorney can help insure business owners’ rights are not being violated and assist in navigating the gray areas of cannabis law. Attorneys will also help set up a legal corporation and the operating agreement of said corporation.


Perception impacts price. Premium pricing techniques are often used when trying to reflect the exclusivity of a product. CBD is mix of both.

While numerous factors make CBD expensive, there are a number of special discounts and CBD assistance programs available to people with low incomes, the disabled, and military veterans among others. Photo: Hands holding a brown glass bottle of CBD oil, and a dropper with a drop of CBD dripping out, against a background of green hemp plants.

While numerous factors make CBD expensive, there are a number of special discounts and CBD assistance programs available to people with low incomes, the disabled, and military veterans among others.

Let’s face it; there is a certain level of mystique and sexiness associated with CBD. The thought of consuming a product that borders on breaking the law presents a sense of danger and excitement. These factors absolutely have an affect on the price of a product, especially for a new product that can also heal! Companies know this and definitely price accordingly.

The good news is in time, when the ‘newness’ wears off and more companies come to market, prices should go down.


Regardless of where CBD prices are currently at, there are things consumers can do to stretch their dollar and reduce the cost of CBD.

The first thing a user can do is to try and cut back on their CBD daily doses. When it comes to CBD more is not better, less is best. The easiest way to cut back is to consume slightly less with each dose. For example, if you normally take 15mg of CBD twice per day, try decreasing each dose to 11 or 12 milligrams each time. This simple move will save roughly 5 milligrams of CBD each day. Our bet is your body will not even miss those 5mg. In case it does, you can always increase the dosage back to 15 mg.

Switch to a lower grade CBD. Experienced CBD users know the term full spectrum all too well. Full spectrum CBD oil is the preferred choice for many, but doesn’t mean it’s the only choice. CBD isolate is definitely a lower grade product, but it does work quite well. In fact, many of the ‘full spectrum’ products actually contain only a small amount of true full spectrum oil and are mixed with an isolate.

Lastly, there are a number of CBD companies that offer discounts to active military and veterans, the disabled and those with low income. We plan to collect some of the best assistance programs into an upcoming article. In the meantime, we recommend searching Google for “CBD assistance program” or check with your preferred CBD brand.


Most of you reading this know that both CBD and industrial hemp were officially legalized this past December under the 2018 Farm Bill.

With this legalization, we’re expecting sweeping reform to take place throughout the hemp industry. It’s safe to say that many companies are eagerly waiting to get in the CBD business. The floodgates will open. From banking and insurance companies to new hemp manufacturers, distributors and retailers, costs across the board should decrease.

Immense pressure is being put on the powers that be to provide federal regulations on CBD products that create quality standards industry-wide. That could get things moving towards lowering costs, too.

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TryTheCBD Vape Cartridges Offer Pure, Smooth Vaping Experience

TryTheCBD Vape Cartridges use a specialized carrier oil designed to be free of irritants, like propylene glycol, commonly found in other vapes. They combine Colorado-grown CBD isolate with delicious plant-based terpenes.

TryTheCBD Vape Cartridges stand out from other cartridges on the market through their high-quality components and pure ingredients.

We loved trying TryTheCBD’s delicious and effective vape cartridges. Vaping CBD is one of the most popular ways to take this beneficial supplement. However, not all CBD vapes are created equal. Some CBD vapes include ingredients like propylene glycol, which can irritate people’s throats.

TryTheCBD Vape Cartridges combine CBD isolate grown under organic conditions, with plant-based terpenes to increase the flavor and effects. Their new formula contains no propylene glycol, vegetable glycerin, or MCT oil. Instead, the CBD and terpenes are mixed into a special carrier liquid called TEC Temper, which is a blend of special additional terpenes designed to reduce inflammation.

The result is an extremely smooth vaping experience, without the typical harshness that can leave your throat irritated. These vape cartridges come in a variety of flavors, each designed to mimic a popular strain of psychoactive cannabis (“marijuana”) without any THC. The result is flavorful and relaxing, without the high. We tried TryTheCBD’s Gorilla Glue #4 and loved the subtle flavor and relaxing effects.

TryTheCBD Vape Cartridges combine CBD isolate with plant-based terpenes in a special carrier fluid free of common irritants, for smooth delicious vaping. Photo: TryTheCBD Vape Cartridges and other TryTheCBD products posedaround a laptop on a wooden desk, with headphones nearby.

TryTheCBD Vape Cartridges combine CBD isolate with plant-based terpenes in a special carrier fluid free of common irritants, to create smooth delicious vaping.

TryTheCBD paid us a fee and offered us free products in return for our honest opinion. If you purchase a product from one of these links, we’ll receive a percentage of sales. Read more about sponsored content on Ministry of Hemp.

Read on for our full review of TryTheCBD Vape Cartridges, to learn more about their great features.


In addition to the unique TEC Temper carrier fluid, TryTheCBD Vape Cartridges offer a number of other appealing features.

These cartridges have a standard threading that fits into almost any vape battery, but inside the cartridge is anything but standard. High-quality ceramic coils and leak proof engineering make these cartridges more durable and give CBD consumers a better vaping experience.

TryTheCBD is a Colorado company that uses all Colorado-grown hemp, produced under organic conditions with no GMO ingredients. All their products are also gluten free. We appreciate that TryTheCBD makes third-party lab results available right in the product listing.

In addition, at $59.99 for 500 mg of CBD, this is a good value for a high-capacity disposable cartridge full of high-quality cannabidol.

TryTheCBD Vape Cartridge, Gorilla Glue #4 (Ministry Of Hemp Official CBD Review)TRYTHECBD VAPE CARTRIDGES OFFICIAL REVIEW

  • Highlights: TryTheCBD makes their Vape Cartridges with a specialized, terpene-bassed carrier oil designed to reduce inflammation and prevent irritation of the throat.  
  • Strength: 500mg disposable cartridge, also available in 300mg cartridges
  • Price: $34.99 – $59.99
  • Customer Service & Shipping: Fast, friendly customer service. Free shipping is available on orders over $99.
  • Independent Test Results: Online.
  • Flavor & Feel: Subtle but delicious and terpene-rich flavor profile. Gorilla Glue #4 has an earthy, faintly sweet and piney flavor. Effects are very relaxing, easing muscle soreness, chronic pain and agitation in our reviewer.
  • Ingredients: CBD isolate in TEC Temper carrier fluid, plus Botanical Terpenes.
  • Other: Available in several great flavors. We loved their “OG Kush,” too. Pre-filled disposable vape pens are also available.

TryTheCBD uses hemp grown under organic conditions in Colorado in all their CBD products. They make a full range of CBD supplements, some of which contain full spectrum CBD, including CBD tinctures and CBD pet products. Learn more about the differences between full spectrum and CBD isolate.

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Using CBD For Sleep: Can CBD Help Treat Insomnia?

We wanted to take a closer look at the science behind CBD as a treatment for insomnia. Millions of Americans suffer from sleeplessness, and conventional treatments often fail or lose effectiveness.

As more people begin using CBD for sleep, we wanted to take a closer look at the science behind cannabidiol as a treatment for insomnia.

Sleep has baffled humans for millennia, and although scientists have tried to unravel its secrets, it is still a bit mysterious. For the 50-70 million Americans with insomnia, it is even more elusive. Standard treatments often lose effectiveness over time and carry risks of dangerous side effects. Finding relief can be a gruelling task.

However, research has shown that cannabidiol (CBD) may be a promising alternative or addition to conventional medications. To understand how people use CBD for better sleep, some basic knowledge of insomnia and the science of sleeping is necessary.


Insomnia is by far the most common of all sleep disorders. People with insomnia struggle falling and staying asleep and suffer from poor sleep quality. As many as 20 percent of adult Americans meet the diagnostic criteria for either primary (independent of outside factors) or secondary (accompanying another illness) insomnia.

During insomnia, the brain goes into flight-or-fight mode, leaving would-be sleepers too alert to drift off. Photo: A house with its lights on at the top floor, with a night time city in the background.

During insomnia, the brain goes into flight-or-fight mode, leaving would-be sleepers too alert to drift off.

When someone with insomnia attempts to fall asleep, their brain enters a state that is known as hyperarousal. During hyperarousal, the body goes into fight or flight mode and is on guard for anything that may be a threat. This increased state of alertness makes it difficult to fall asleep, remain asleep and get restful sleep.


Approximately 70-90 percent of people with insomnia have a mental or physical illness that is the primary cause. Over-the-counter, prescription and illegal drugs can also cause insomnia. Occasionally, it affects people independent of any outside factors.

Physical conditions that can lead to insomnia include asthma, heart disease, chronic pain, seizures, renal dysfunction, and Alzheimer’s. Most psychiatric conditions can lead to sleep disturbances, especially depression and anxiety. Secondary insomnia often results in a vicious cycle were sleeplessness worsens the primary disease, which worsens insomnia.


Doctors manage insomnia using pharmacological and behavioral treatment methods. Non-medicinal treatment includes stimulus control, cognitive behavioral therapy or relaxation therapy. These include breathing techniques, progressive muscle relaxation, mindfulness, and meditation.

Benzodiazepines, non-benzodiazepine hypnotics (sedative medications used for the treatment of insomnia and during surgical procedures) and melatonin receptor agonists are standard pharmacological treatments. Over-the-counter sleeping pills and supplements, like synthetic melatonin, are another common medication taken to manage insomnia.


Hypnotic medications used to treat insomnia are known for their potential to cause grave side effects. These include addiction, severe allergic reaction, memory lapses, hallucination, suicidal thoughts or actions, and abnormal sleep behaviors like sleepwalking. They may also lose effectiveness as tolerance is built or cause complications from drug interactions when another condition requires medication.

Among patients treated with pharmaceutical and over-the-counter medications, 48 percent report being dissatisfied with the amount of time it takes to fall asleep (sleep onset latency or SOL) and wake up. A 2001 study of 30 insomnia patients found medication coupled with relaxation therapies caused SOL to plummet from 124 to 29 minutes. The participants using only pharmaceuticals did not experience a change in sleep onset latency, suggesting hypnotics alone are not always successful.


To understand how cannabidiol can boost sleep it is necessary to understand the biological process responsible for inducing sleep. In humans, circadian rhythm governs a 24-hour sleep schedule that is regulated by the hormone melatonin, a product of the pineal gland. This process begins with the retina; during the day a signal is sent from the eye through the brain, down the spinal cord and back up to the pineal gland, telling it to refrain from making melatonin.

At night, these signals do not activate, allowing the pineal gland to begin producing melatonin. The amino acid tryptophan is absorbed into the pineal gland via the bloodstream, then converted into 5-hydroxytryptophan by the enzyme tryptophan hydroxylase. It is then turned into serotonin by the enzyme aromatic amino acid decarboxylase before finally becoming melatonin.


Cannabidiol may help stimulate melatonin production by boosting levels of tryptophan in the bloodstream; this is accomplished by reducing tryptophan degeneration caused by mitogen, the protein that tells cells to divide. CBD improves serotonin production in the same way, as an increase in tryptophan availability aids in serotonin synthesis in the brain.

Using CBD for sleep may increase melatonin levels and help ease health conditions that cause insomnia. Photo: A dark-skinned woman sleeps on a bed with white sheets, while a light shines on a nightstand.

Using CBD for sleep may increase melatonin levels and help ease health conditions that cause insomnia.

Inflammation adversely affects tryptophan cells and CBD reduces inflammation. When tryptophan is readily available in the bloodstream, the pineal gland can produce melatonin more effectively, leading to better sleep. Small doses of CBD may also help improve daytime wakefulness, helping to reset the 24-hour sleep cycle and restore balance over the long-term.

A 2018 study tracked 409 patients with insomnia during 1059 medical marijuana administrations using an educational app. Participants reported their self-perceived insomnia symptoms before and after using cannabis. On average, users reported a 4.5-point decrease after consumption, using a 0-10 visual analog scale. Researchers found that cannabis strains with higher cannabidiol levels more effectively relieved insomnia than ones with higher tetrahydrocannabinol levels.


Cannabidiol alleviates many of the primary conditions associated with secondary insomnia through its antioxidant, analgesic and anti-inflammatory properties. It has proven useful in mitigating symptoms of anxiety, depression, chronic pain, and autoimmune disease, among others. It also helps control the endocannabinoid system, which regulates mood, pain, appetite, cognitive function, and other biological processes.

A 2015 case study showed cannabidiol was effective in treating insomnia induced by anxiety and post-traumatic stress disorder. The subject, a 10-year-old girl, had been abused and was being prescribed pharmaceutical treatments. However, these were only partially effective over the short-term and caused extreme side effects.

Over 5 months, the girl took 25 mg CBD supplements at bedtime and 6-12 mg sublingual doses as needed during the day to control anxiety. After 5 months, the girl’s score on the Sleep Disturbance Scale for Children had decreased from 59 to 38, indicating she no longer suffered from insomnia.


Research haven’t determined the best dose of CBD for sleep onset latency. However, a 2014 study found a 15 mg dose of CBD increased alertness, suggesting a higher dosage would work more efficiently for treating insomnia.

A 2018 study of medical marijuana users found cannabis strains with higher cannabidiol levels more effectively relieved insomnia than ones with higher tetrahydrocannabinol levels.

Unlike traditional sleeping pills, research demonstrates cannabidiol is relatively safe. CBD does not appear to be habit forming, even in very high doses. For example, a 2018 study found that an oral dose of 750 mg of CBD did not show potential for abuse among 43 people with a history of using two or more drugs for recreational purposes (polydrug use). Hypnotic medications alprazolam and dronabinol demonstrated a risk of dependency among the same participants.


It is vital for anyone experiencing distress or impairment from insomnia to seek the advice of a healthcare professional. Poor sleep quality can negatively influence productivity, mental health, and cardiac function.

While some individuals find success using medicinal marijuana to treat insomnia, research suggests tetrahydrocannabinol may impair sleep quality long-term. Cannabidiol on its own is not shown to have the same risks. However, individuals taking pharmaceutical medications should consult with a physician prior to taking CBD.


Studies from as far back as 1972 consistently demonstrate the potential of cannabis to improve sleep. New research focused specifically on cannabidiol is exhibiting the same positive results, with little potential for adverse long-term effects. Using CBD for sleep is shaping up to be a promising alternative to some risky and inefficient hypnotic medications.

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CBD Inhalers: Innovation In The CBD Market From CBD Luxe

An innovative new CBD inhaler could help change how people view CBD and hemp. Unique CBD inhalers from CBD Luxe offers people an easy and reliable way to get their dose of CBD, in a product that looks like any other medical device.

An innovative new CBD inhaler could help change how people view CBD and hemp.

One of the biggest challenges within the CBD industry is getting people to open their minds to the medical benefits of hemp. How is CBD Luxe addressing these problems?

By providing the market with a product which looks all the same as anyone might use for their medical condition — a CBD inhaler.

Before creating CBD Luxe, co-owner William Spilo snowboarded professionally and worked as an international heli-skiing guide. He suffered multiple injuries through his work over the years — some reaching traumatic levels. After being stuffed full of pain medications such as NSAIDS (nonsteroidal anti-inflammatory drugs), he was introduced to CBD.

“I was on a pretty heavy regimen of NSAIDs every day and I was seeing if there were alternatives to that,” Spilo explained. “I got some CBD mint and I couldn’t believe the effects. So, I did one line of test runs and handed it out to all the professional athletes I work with and the results were astonishing.”

CBD Inhalers from CBD Luxe offer a reliable, easy to inhale dose of full-spectrum CBD oil.

CBD Inhalers from CBD Luxe offer a reliable, easy to inhale dose of full-spectrum CBD oil.

We talked with Spilo in order to learn more about his company’s newest line of products, CBD inhalers.


“We’re trying to broaden the consumer base. It’s called a meter dose inhaler as we want to give precision dosing so the consumer knows exactly how much they’re getting every time. We’re also providing a comfortable, safe delivery system.”

CBD Luxe makes their inhalers from the same FDA approved material used for asthma inhalers. Each CBD inhaler contains 1100mg of micellized CBD. Micellization is the process of formulating molecules into colloidal solutions. This means the CBD is evenly distributed throughout, allowing each dose to be the same as the last.

CBD Luxe offers 4 different CBD inhalers with different natural extracts to help consumers achieve different experiences. There’s also a pure CBD inhaler with no additional ingredients. This full spectrum hemp oil offers users over 200 doses per inhaler.

The 2018 Farm Bill opened doors for innovating products such as these inhalers. As time progresses, we’re bound to continue seeing novel ideas within products, mixtures, and other uses for hemp. As we discussed these inhalers with Spilo, we kept these thoughts in mind to get a taste for the future of CBD.


“When we [CBD Luxe] started in early 2016, there weren’t many CBD products on the market,” Spilo told us.

Not to mention, there remained a complete lack of public knowledge as to what CBD was. In the eyes of the federal government, hemp was still considered a Schedule I drug.

Yet, people like Spilo not only saw an opportunity but also a misunderstood medicine which could help millions of people. With that, he figured, “we’d make a higher quality product out there that was a little more targeted for what CBD can do for the consumer.”

Since the CBD industry is so constantly evolving, there are a number of problems which still need to be addressed. One of these is accurate labeling. Not only do they test every ingredient which comes into their facility but they also provide clear labels about what’s in their product. Furthermore, CBD Luxe is committed to providing the user with all the information about what’s in their CBD.

When Spilo entered the market, he noticed there weren’t many companies offering molecular isolates. This is when CBD is extracted into a water-soluble form. Though there were some products, Spilo and his team found some of these companies had “metal content and impurities in the CBD were at risk to the consumer.”

Just as with any responsible company, CBD Luxe tests all their products with a third-party lab to ensure accuracy and purity.


As more companies with the same business models came into the market, people inevitably gravitated towards the hemp industry.

“Still, we also felt we could enhance the effects of CBD by using botanicals,” Spilo recalled. “For vape pens, we’re using essential oils. For consumables and inhalers, we’re using full botanical extract. All of our ingredients are organic and non-GMO — except for the CBD itself because we have no certification for that yet. So, we just felt we’d make a higher quality product out there that was a little more targeted towards what CBD could actually do for the consumer.”

It’s thanks to efforts as such that the acreage of hemp cultivation was able to triple within a one-year period. Thanks to federal legalization, the industry is looking very optimistic. With that, questions begin to arise about the future of CBD.


Understandably, not every void within the CBD marketplace has been filled. As this industry continues to build itself, it’s inevitable for more problems needing to be addressed. It helps to take a look at how the market is going now in order to predict these complications before they arise.

“I think right now there are quite a few good products out there,” Spilo mentions. “I do think we have to watch out for the level of purity and the content. So, what is the CBD they’re putting in there? And how much? It’s important to have an understanding of what you want out of the product and what you’re looking for. We’d like to help steer you towards a more specific product.

“Since the passing of the Farm Bill in late 2018, the industry is really flooded. I mean, we’ve really gained a lot of recognition.”

As expected, this flooded market has a lot of questions. Now it’s the responsibility of companies such as CBD Luxe to not only answer these questions but create products which respond to the public’s growing desire.

CBD Luxe has been experimenting with their CBD inhaler formulas for some time now. And they’re constantly continuing these experiments to provide new experiences of CBD.

If you’re interested in learning more about these inhalers and/or purchasing one, you can check out the product’s page here.

Out of curiosity, we asked if CBD Luxe had any further innovative products in mind. Spilo’s response:

“There are a few that we’re working on, but …” Spilo laughed, “… we don’t want to release anything we aren’t sure of to market.”

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Shauna’s Law: Kentucky Bill Would Protect Workers Taking CBD

Named for an EMT from Powell County, Kentucky, Shauna’s Law would protect workers taking CBD from being fired due to failed drug tests. It could serve as a model to other states, too.

A proposed law in Kentucky would protect workers taking CBD from retaliation from their employer.

What happens when CBD shows up on a drug test as THC? Hemp-derived CBD supplements have only miniscule amounts of THC, the active ingredient in psychoactive cannabis (“marijuana”) that makes people feel high. However, imprecise testing methods can sometimes create a false positive result for marijuana use.

This is exactly what happened to Shauna Staton, an EMT in Powell County, Kentucky. Though she was only using CBD for pain relief, her employers accused her of having trace amounts of psychoactive cannabis in her system after a failed drug test. Her employer immediately fired her.

Of course, Staton protested against these allegations. According to Staton, she only used legal CBD products from Bluegrass Hemp Oil. After filing an appeal, Staton got her job back.

Shauna's Law, a bill in Kentucky could protect the rights of workers taking CBD. A woman takes a supplement in an office.

Shauna’s Law, a bill in Kentucky, could protect the rights of workers taking CBD.

However, the fact that using CBD can still pose risks proves there’s a need for change in legislation. And that’s exactly what “Shauna’s Law” aims to do in Kentucky.


The bill seeks to protect workers using CBD products within drug-free workplaces. It lays out an appeal process for all public employees in drug-free work environments who fail a drug test. An employer must allow their employee to complete an appeal as long as the employee:

  • Uses legal industrial hemp CBD products
  • Can provide a purchase receipt of said product
  • Produces test results that correspond with an industrial hemp product (less than 0.3 percent THC)

A bill as such not only helps those who truly need CBD products, but also educates the public on the difference between hemp and marijuana.


We were lucky to have a discussion with Adriane at Bluegrass Hemp Oil on the matter to get her insight on how Shauna’s Law can change the CBD industry.

“We’ve been here to support her all throughout her pushback,” she told us. She continued:

“But she did it all herself. There’s a lot of determination on her part and we respect her for it. She didn’t ask for anything from anybody else. She knew what she was doing was right and wanted to fight for the rights for it.”

Bluegrass Hemp Oil warns all their consumers that their full spectrum products will have trace amounts of THC. The legal limit is 0.3 percent. And they warn their consumers of this because Staton isn’t the first to run into trouble with her employer.

“We’ve heard from not only our consumers but consumers of hemp products throughout the U.S. that have had similar things happen to them,” Adriane explained.

While Shauna's Law would only protect workers taking CBD in Kentucky, it could serve as a model to other states. The Kentucky State Capitol building.

While Shauna’s Law would only protect workers taking CBD in Kentucky, it could serve as a model to other states.

According to Adriane, people within Kentucky are aware of the importance of this law. They’ve “come out either on our Facebook page or called us because they want to get really active here within the state and help us. [They want to] call their legislators and explain the importance of passing this piece of legislation.”


The true importance of this bill is the fact that it’s the first of its kind. Though it only pertains to the state of Kentucky, it’s an example for other states who are bound to propose similar laws. Adriane told us:

“If we can get it done here in Kentucky, I absolutely think it would be something great we could advocate for across the other 49 states.”

Adriane suggested other states can use Senate Bill 83 (“Shauna’s Law”) as a model.

She claimed, “It’s a very simple piece of legislation that I think any state can mimic.”

She suggested workers taking CBD may want to inform their employers prior to a drug test. When in doubt, she added, you should request a secondary test which shows the level of THC metabolites.

“In Shauna’s case, she tested positive for 30 nanograms [of THC],” Adriane explained. “That’s a really minute amount.”

Shauna’s Law is unique in what it asks for. We’ll continue to see new laws appearing from state to state since both the hemp industry and consumers need legal protection. As Adriane puts it:

“I think if the hemp industry is going to continue on its upwards rise and CBD products are going to continue to be put on shelves throughout the United States, [Shauna’s Law] is something that needs to be addressed. We have to put something in place that gives consumers the confidence to try these healing products.”

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CBD vs. CBN: Differences, Benefits, And Uses For Two Potent Cannabinoids

In this article, we compare the benefits of CBD vs. CBN. Both of these cannabinoids help create the “entourage effect” in hemp and cannabis that can help us live better lives.

Cannabidiol — also known as CBD — has been getting a lot of attention lately.

As it dominates headlines, sparks controversies, and finds its way onto menus in coffee shops across the country, you could even say that CBD is on track to becoming as well-known as its cousin, THC.

With all the focus on CBD, it’s easy to forget that there’s over 100 other cannabinoids out there, of which CBD and THC are only two. And among all of these naturally occurring cannabis-derived compounds, many have their own powerful therapeutic benefits that are on par with CBD. So with that in mind, which cannabinoid is next in line for its time in the spotlight?

In this article, we compare the benefits of CBD vs. CBN and explain how both can help us live better lives. A seated person cups a mug of coffee in their hands in front of a laptop. Arranged nearby are a small plant, a notepad, a smartphone, a bottle of Every Day Optimal CBD, and decorate letters spelling the word DREAM.

In this article, we compare the benefits of CBD vs. CBN and explain how both can help us live better lives. (Photo: Every Day Optimal)

Our nominee: CBN, short for cannabinol. In this article, we’ll dive into what CBN is, what its benefits are, and how it compares with CBD.


Just in case you’re new to the world of cannabinoids, CBD is one of the primary compounds found in the cannabis plant (which includes both hemp and marijuana). CBD can make up anywhere from 1 percent to 25 percent of the plant, and in most strains, it’s the second most dominant cannabinoid next to THC. While THC is best known for its psychoactive properties, CBD won’t get you high; rather, its skyrocketing popularity is based entirely on its wide range of therapeutic benefits. Many consumers are touting the benefits of using CBD gummies and edibles for daily stress and anxiety, while others use the oils, balms and capsules for ailments like muscle pain, insomnia, and depression.

CBN is a bit different from CBD for a few reasons. Its content in cannabis tends to be pretty low – 1 percent or even less — but this is subject to change over time as the plant is exposed to oxygen or heat. Specifically, as cannabis ages, its THC content breaks down into CBN. Additionally, while CBD has zero psychoactive properties, the same can’t be said for CBN; that said, its psychoactive properties are very, very mild, so you’d likely need to take a massive dose of CBN to feel any sort of high.

Although CBN may be new to you, it was among the very first cannabinoids ever identified, and was successfully isolated for the first time in the 1930s. In fact, prior to the discovery of THC, CBN was considered to be the cause behind the psychoactive effects of marijuana.


Despite CBN being on scientists’ radar for so long, research on its use is very limited — especially when compared to the wealth of information available for both CBD and THC. That said, what we know so far about this cannabinoid is promising.

One of CBN’s biggest benefits is that it’s a strong sedative, making it effective as a sleep aid and anti-anxiety drug. According to Steep Hill Labs, CBN’s relaxing effects are comparable to the pharmaceutical diazepam, while a 1995 study on mice found that CBN can increase sleep time as well. Additionally, CBN’s effectiveness for sleep is enhanced when taken alongside CBD, which has been praised for its ability to increase REM sleep, reduce nightmares, and treat sleep disorders such as insomnia and sleep apnea.

Aside from sleep benefits, both CBN and CBD are potent anti-inflammatories with powerful pain relieving properties. Again, these benefits appear to be even more effective when both cannabinoids are taken together. Both CBN and CBD can also relieve pressure related to glaucoma, and both have antibacterial properties, including against antibiotic-resistant MRSA. Among other benefits, CBD is a powerful treatment for epilepsy and anxiety disorders, and CBN shows promise as an appetite stimulant as well.

Full spectrum hemp extracts feature both CBD and CBN among other cannabinoids, promoting the "entourage effect." A person drops a dropperful of CBD oil from a bottle of Every Day Optimal into a cup of espresso.

Full spectrum hemp extracts feature both CBD and CBN among other cannabinoids, promoting the “entourage effect.” (Photo: Every Day Optimal)


If you’re looking to get the most out of CBD and CBN, you’ll want to pick up some full spectrum or broad spectrum CBD oil, as these types of CBD oil contain both compounds. Full spectrum and broad spectrum CBD oils are similar, with one crucial difference: THC.

Full spectrum CBD oil contains all the cannabinoids and terpenes that were extracted from the cannabis plant, including CBD, THC, CBN, and a variety of other compounds that vary depending on the strain. Broad spectrum CBD oil, on the other hand, goes through additional processing to remove all traces of THC, while keeping all other cannabinoids intact.

Full spectrum CBD oil is a popular choice due to what’s called the “entourage effect.” Essentially, the benefits of each cannabinoid are enhanced when taken together. This includes THC and CBD, CBD and CBN, and so on. Meanwhile, broad spectrum CBD oil is ideal for those who desire the benefits of full spectrum CBD oil, but who can’t have any traces of THC.


As you can see, CBN shows a lot of promise for a wide spectrum of issues.

At Every Day Optimal, we believe, that just like CBD, it can be quite powerful for pain relief, sleep troubles, and anxiety. When CBN is taken with CBD, these benefits are often even more potent. With all the attention CBD’s gotten lately, it’s likely that we’ll see much more research into the benefits of CBN and other cannabinoids in the near future.

And who knows – maybe CBN will start showing up in coffee shops next, right alongside CBD. We’ll be keeping an eye out for it!

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CBD For Bipolar Disorder: Can Cannabinoids Help Treat Bipolar Affective Disorder?

4.4 percent of adults are estimated to experience bipolar affective disorder. We took a look at research suggesting CBD and other cannabinoids could help.

We wanted to take a closer look at the science behind using CBD for bipolar affective disorder.

The National Mental Health Institute estimates 4.4 percent of adults in the United States will be given a diagnosis of bipolar affective disorder (BPAD) in their lifetime. Adults with BPAD experience the highest rate of impairment among psychiatric patients; an estimated 82.9 percent suffer from severe disablement.

Bipolar affective disorder and its variants can be treatment resistant, which may explain the high rate of disability. Anecdotal evidence, supported by preliminary studies, suggest that cannabinoids have the potential to improve the symptoms of BPAD in some individuals by regulating the endocannabinoid system.


Bipolar affective disorder is a mental illness that causes significant changes in mood, motivation and energy. A process known as cycling, which involves periods of euphoria (manic episodes) followed by hopelessness (depressive episodes), is a hallmark of the illness.

A man hands holding a white paper sheet with two faced head over a crowded street background.

Some preliminary research supports the use of CBD for bipolar affective disorder treatment.

There are four variants of bipolar affective disorder: bipolar I, bipolar II, cyclothymic disorder and bipolar spectrum disorders. The severity and frequency of symptoms are used to determine which variant is diagnosed. Bipolar I is the most severe form of the disease.


Manic episodes, sometimes referred to as mania, are characterized by exaggerated self-esteem, insomnia, racing thoughts and abnormal speech, inability to focus, and impulsive behaviours. True manic episodes only affect those diagnosed with bipolar I disorder. However, patients with other variants of BPAD experience hypomania, a less severe form of mania.

Although mania is considered to be the “high” stage of BPAD, it can have disastrous consequences. Many manic episodes result in hospitalization, psychotic symptoms or grave impairment (e.g., risky behaviour leading to legal trouble). Untreated manic episodes can develop into psychosis.


Depressive episodes mimic a severe form of depression known as major depressive disorder. Symptoms can include feelings of sadness, emptiness, hopelessness, and loss of interest in activities. Additional traits of depressive episodes are changes in sleep patterns and appetite, trouble concentrating, feelings of worthlessness or guilt, and suicidal thoughts or attempts.

This cycle of bipolar disorder is the “low” point of the disease. Like mania, depressive episodes vary in severity depending on which variant of bipolar disorder is present. Patients with Bipolar I disorder may have what are known as mixed episodes, during which they show signs of both mania and depression.


Prescription drugs used in conjunction with psychotherapy can help alleviate symptoms of BPAD in most patients. However, bipolar affective disorder can be treatment-resistant, making it difficult to manage in some people. Treatment-resistant BPAD is cause for concern, as up to 50 percent of individuals diagnosed will attempt suicide at least once in their lives.

Medications prescribed for BPAD include anticonvulsants, antimanic drugs and antidepressants. Use of antidepressants alone can lead to the onset of mania or rapid cycling. Mood stabilizers or anticonvulsants are often taken to negate these possible side effects.

The only pharmaceutical shown to have a consistent, positive effect on suicide rates in bipolar patients is lithium. However, newer research has shown there may be a possibility to control BPAD through manipulating the endocannabinoid (EC) system. These are the neurotransmitters responsible for binding cannabinoid proteins to receptors.


The endocannabinoid system, discovered in the mid-1990s, is comprised of two receptors, CB1 and CB2. Cannabinoids, a type of compound found in both the human body and cannabis plants, bind to these receptors to alter brain function. Endocannabinoids are neurotransmitters produced naturally in the body, while phytocannabinoids are found in cannabis plants.


An illustration of neurons firing in a human head. Post-mortem studies of human brains of people with bipolar affective disorder found some abnormalities in how they process cannabinoids.

Post-mortem studies of human brains of people with bipolar affective disorder found some abnormalities in how they process cannabinoids.

Postmortem studies have found that brains of patients diagnosed with mental illness, including BPAD variants, show abnormalities in the endocannabinoid system. A similar study, conducted using brain slices from mice, showed dysfunctional CB2 receptors inhibited the release of serotonin, suggesting a healthy EC system helps to regulate mood.

An investigation of endocannabinoid gene variants in 83 patients with major depressive disorder (MDD), 134 with BPAD, and 117 healthy control participants found two marked differences in the patients afflicted with MDD and BPAD. Specifically, the CB1 receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes of the ill participants were found to be abnormal when compared to the control group.


Because of the distribution of endocannabinoid receptors throughout the brain, many of the areas they affect overlap with regions thought to be responsible for BPAD, along with other mental illnesses. Studies have shown patients with specific abnormalities in the CNR1 gene are at a higher risk of being resistant to pharmacological treatment, leaving them more vulnerable to the effects of bipolar affective disorder.

For these patients, phytocannabinoids could provide a way to manipulate the EC system and regulate the level of chemicals traditionally targeted by pharmacological medications. As always with hemp and cannabis research, these studies are still preliminary. More research will be needed to prove whether CBD and other cannabinoids can help treat bipolar affective disorder.

Anandamide and THC

Anandamide, called the bliss molecule, is naturally produced in the body and is similar in molecular structure to THC. Both anandamide and THC bind to CB1 receptors, altering areas of the brain responsible for memory, concentration, movement, perception, and pleasure.

FAAH genes are responsible for activating anandamide; indicating people with FAAH gene mutations may not have the appropriate levels of anandamide in the brain. Supplementing brains deficient in anandamide with THC may help restore chemical balances. Theoretically, this could alleviate cycling between manic and depressive phases.

Cannabidiol (CBD)

Cannabidiol has been shown to inhibit serotonin reuptake in rats, suggesting it repairs abnormalities in CB1 receptors found to inhibit release in mice. If CBD functions the same in human brains, it could provide an alternative to conventional antidepressants, especially for individuals with treatment-resistant BPAD.

A randomized clinical trial found CBD reduces abnormal brain function in regions associated with psychosis, implying it may have therapeutic effects on symptoms associated with the manic phase of BPAD. If CBD regulates both depressive and manic symptoms, it could help treat individuals who do not react well to lithium.

Other Cannabinoids

Cannabis is a complex compound, made up of over 500 chemicals. Over 100 of these compounds are suspected to be cannabinoids. There is little information on the effects of these chemicals, apart from CBD and THC, because few studies have focused on determining what reactions they produce in the EC system.

Among cannabinoids that have already been isolated, CBG and CBCV seem to show a potential for treating mood disorders, such as depression. Further study may help isolate more of these chemicals and determine what effect they have on the EC system.

A gloved scientist with a vial of CBD and a hemp leaf. Preliminary research supports further investigation into using CBD to treat bipolar affective disorder.

Though research is just beginning, it seems likely that CBD and other cannabinoids could help people with bipolar affective disorder.


CBD rarely causes adverse reactions. Still, there are risks associated with both conventional methods of treatment and using cannabis derivatives as treatment. The most dangerous side effect of any treatment for BPAD is the potential worsening of symptoms.

Individuals experiencing symptoms of bipolar affective disorder, or previously diagnosed with any of the variants, should consult with a medical professional before starting or changing treatment. Even those who present with treatment-resistant variations of the disease can benefit from traditional methods (such as psychotherapy).

Regulating the EC system through phytocannabinoids may provide a way to alleviate symptoms in those with treatment-resistant BPAD. Further clinical trials in humans are needed to validate preliminary data, but the future of cannabinoids as a BPAD treatment looks promising.

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Curaleaf Hemp CBD Lotion Moisturizes While Relieving Pain

Curaleaf Hemp CBD Lotion offers pain relief with full spectrum hemp extract and a creamy, herbal, bright scented twist. We loved the unique creamy texture and wonderful smell of this lotion.

Curaleaf Hemp CBD Lotion offers pain relief with full spectrum hemp extract and a creamy, herbal, bright-scented twist.

CBD can help reduce inflammation and soreness and offer general pain relief. Topical CBD products can offer numerous benefits. However, Curaleaf Hemp offers something extra with this unique skin lotion made from high quality ingredients.

We’d love this lotion even without CBD. Our reviewer was tempted to use it on her entire body, but the instructions recommend limiting the application area. It works best for people with pain hot spots or specific areas of inflammation. The lotion itself is made with some of the best lotion ingredients including essential fatty acids like shea butter, as well as coconut, argan, and sunflower oils. Another health and skin protectant powerhouse ingredient is aloe vera.

In addition to 300mg of CBD, lemongrass and rosemary are two herbal aids that increase the anti-inflammatory properties of this delightful topical. Curaleaf Hemp CBD Lotion is wonderful for folks who enjoy a bit of aromatherapy and herbal remedy with their CBD pain relief. They also offer an option with menthol for those who prefer a cooling sensation.

A photo of Curaleaf Hemp CBD Lotion in lemongrass and menthol scents, decorated with fresh herbs.

Our reviewer loved the creamy texture and relaxing scent of Curaleaf Hemp CBD lotion.

Curaleaf Hemp paid us a fee and offered us free products in return for our honest opinion. If you purchase a product from one of these links, we’ll receive a percentage of sales. Read more about sponsored content on Ministry of Hemp.

Read on for our full review of Curaleaf Hemp CBD Lotion.


With Curaleaf Hemp CBD Lotion we didn’t have to worry about sticky, wet hands; it absorbed quickly. And the scent and relief lasted even after washing our hands within an hour of application. The label advises application up to 4 times per day. Our reviewer used it about 2 times per day and found relief lasted for a few hours.

With an old knee injury that tends to flare up after a day on her feet, our reviewer was able to massage about a nickel sized dollop onto her swollen tendons and around her knee cap with ease before going to bed. We also think it’s great after a warm shower. After about 5-10 minutes, she reported feeling a slight tingling sensation and that her leg felt more relaxed. Our reviewer even noticed her leg wasn’t as tight the next day while doing her morning stretches.

Typing, texting, and the beginnings of carpal tunnel and arthritis are a part of modern life. In the mornings before work, our reviewer enjoyed rubbing about a dime sized portion of the lotion into each of her sore, tight wrists and hands, relieving pain and relaxing appendages before a day at the office. We think this lotion is great for a hand or foot massage too.

They use full spectrum, U.S. grown CBD hemp extract in all Curaleaf Hemp products, and they provide a helpful breakdown on how topical CBD works on their site. Curaleaf made a name for themselves as providers of top-quality medical cannabis products, and we’re happy to report they’ve brought the same care to their Curaleaf Hemp brand.

Curaleaf Hemp CBD Lotion with Lemongrass (Ministry of Hemp Official CBD Review)CURALEAF HEMP CBD LOTION OFFICIAL REVIEW

  • Highlights: Curaleaf Hemp CBD Lotion is an excellent moisturizing product that uses high-quality full spectrum CBD hemp extract to ease soreness and inflammation within minutes of application.
  • Strength: 300mg/4oz jar
  • Price: $44.99
  • Customer Service and Shipping: Fast, friendly customer service. Standard shipping starts at $4.99.
  • Independent Test Results: Available on request.
  • Scent & Texture: Lemongrass with rosemary, argan oil undertones, infused into a creamy, whipped lotion.
  • Ingredients: CBD oil / Full Spectrum Hemp extract with Aqua (distilled water), Butyrospermum Parkii (Shea) Butter, Cetearyl Alcohol (and) Cetearyl Glucoside, Tapioca Starch Modified, Organic Aloe Barbadensis (Aloe Vera) Leaf Juice, Caprylic Capric Triglyceride, Aroma (Lemongrass), Helianthus Annuus (Sunflower) Seed Oil, Organic Argania Spinosa (Argan) Kernel Oil, Organic Cocos Nucifera (Coconut) Oil, Glycerin, Citric Acid, Organic Rosmarinus Officinalis (Rosemary) Leaf Extract, Xanthan Gum, Glyceryl Caprylate.
  • Other: They also offer a menthol scented CBD lotion and topical pain-relief patches.

Curaleaf Hemp uses CO2 Extracted, U.S. Grown hemp in all their products. We also love their unique CBD tincture formulations, each designed for a specific need.


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